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Heart-related conditions such as heart attacks are on the rise across the country, with doctors warning about the increasing presence of high LDL cholesterol, also known as "bad cholesterol," especially among India's younger population. This silent threat is a major contributor to heart disease, one of the leading causes of death in the country, accounting for nearly 7.8% of total mortalities. High LDL cholesterol plays a crucial role in blocking arteries and triggering conditions like atherosclerosis and strokes. It is well-documented that LDL cholesterol tends to accumulate and form plaque, leading to blockages in the arteries and restricted blood flow. The concerning part is that high LDL cholesterol, like many heart conditions, often shows no symptoms until it's too late. By the time symptoms like chest pain appear, a cardiac event could already be in progress.

Compared to Western populations, Indians tend to have higher levels of LDL cholesterol and lower levels of HDL cholesterol, the "good" cholesterol that helps remove LDL from the bloodstream. This is why doctors recommend cholesterol screening starting at 18 years of age to detect silent threats early and take preventive action. Even individuals who appear physically fit can have high LDL cholesterol. For instance, Ajay from Delhi, in his 30s, who exercises regularly and eats healthily, was surprised to discover high LDLC during a routine test. His cardiologist explained that elevated LDL cholesterol could have various underlying reasons and advised him to continue medical therapy alongside his healthy lifestyle.While lifestyle changes such as a healthy diet, regular exercise, and stress management are important, they may not always be sufficient. Doctors stress that medical therapy should not be delayed or neglected, especially if LDL cholesterol levels exceed the target range.

Every individual's journey through treatment is unique, influenced by factors such as age, family history, diabetes status, or previous cardiac events which determine their ideal LDLC targets. Personalized treatment plans are crucial in addressing these factors. Seeking professional medical advice and actively participating in treatment is vital for effective management.

However, in India, only around 60% of patients adhere to their prescribed medication, a concerning trend. Misconceptions often lead individuals to discontinue their medication, resulting in a spike in LDL levels and an increased risk of cardiovascular issues. Additionally, factors like stress, poor sleep, and metabolic imbalances can contribute to elevated LDLC levels, leading to chronic inflammation and heightened cardiovascular risk.

For patients who do not respond well to traditional statins, advanced therapies such as PCSK9 inhibitors, siRNA therapy, or inclisiran are increasingly being recommended. These targeted treatments offer promising results in helping patients achieve their target LDLC levels when standard options prove ineffective. It is important to note that high LDL cholesterol may not exhibit symptoms, yet its consequences can be fatal. Whether you are actively engaged in physical fitness or have never considered your cholesterol levels, it is crucial to undergo screenings, stay informed, and adhere to your treatment plan for a healthier heart.